In cocktails
A 1 litre bottle of Southern Comfort.Southern Comfort is used in the creation of many popular 
cocktails, including “Alabama Slammer”, “Red Death”, “A Piece of Ass”, “Red Devil”, “Greek Sex on the Beach”, “Crash & Burn”, “‘57 Chevy”, “Sloe Comfortable Screw”, “SloScrew”, “Slo Sunrise”, “Rickstasy”, “SocaCola”,”SoCoCello” and “SoCo-LoCo”, “SoCo Manhattan”, “Blind Andy”, “SoCo Andy”, “Liquid Cocaine”, “Steamboat” and “Funky Cold Medina. “Southern Comfort and club soda make a drink called “an old woody”.
One of the earliest Southern Comfort-based cocktails to be marketed was the Scarlett O’Hara, concocted in tribute to the release of the film adaptation of Gone with the Wind in 1939. The mixture includes Southern Comfort, cranberry juice, and fresh lime.
In a more recent advertising campaign, the company suggests mixing it with lime juice to make a Soco and lime.
When Southern Comfort is taken as a shot and chased with orange soda, it gives the distinct taste of an Orange Creamsicle. Another popular mix that incorporates juice is the “Adam’s Apple,” a combination of Southern Comfort and apple juice. Apple cider can also be used in this drink.
In New Zealand, Southern Comfort is often mixed with Lemon & Paeroa.